Recently there has been great interest in applying state-of-the-art machine learning methods to problems in Bio- and Chemoinformatics. The success of kernel methods and the development of kernels which operate over discrete structures such as strings and trees opens up many possibilites for progress in these fields.
This project would focusses on using kernel methods for cheminformatic tasks, such as, in the first instance, developing predictive models which generalise well across chemical series. We are investigating among other aspects the construction of new kernels which can represent molecular structures in a more structured way than the traditional vector-of-statistics approach, which in turn would hopefully lead to greater accuracy on predictive tasks.
The concept of Provenance is already well understood in the study of fine art where it refers to the trusted, documented history of some work of art. Given that documented history, the object attains an authority that allows scholars to understand and appreciate its importance and context relative to other works of art. Objects that do not have a trusted, proven history may be treated with some scepticism by those that study and view them. This same concept of Provenance may also be applied to data and information generated within a computer system; particularly when the information is subject to regulatory control over an extended period of time.
Today's grid architectures suffer from limitations, such as lack of mechanisms to trace results and infrastructures to build up trusted networks. Provenance enables users to trace how a particular result has been arrived at by identifying the individual and aggregated services that produced a particular output. The overarching aim of the Provenance project is to design, conceive and implement an industrial-strength open provenance architecture for grid systems, and to deploy and evaluate it in complex grid applications, namely aerospace engineering and organ transplant management. This support includes a scalable and secure architecture, an open proposal for standardising the protocols and data structures, a set of tools for configuring and using the provenance architecture, an open source reference implementation, and a deployment and validation in industrial context.
The impact of this project is to provide mechanisms that allow information generated and managed within a grid infrastructure to be proven and trusted. By this we mean that the information's history, including the processes that created and modified it, are documented in a way that can be inspected, validated and reasoned about by authorised users that need to ensure information controls have not been altered, abused or tampered with.
As part of the IBM Linux Laptop Challenge, a team of undergraduates has set up a TV service over part of the School's wireless network using the latest IPv6 infrastructure. The multichannel TV service (which will eventually be extended to cover the whole University) has already begun test broadcasts consisting of ECS lectures (both live and repeated) and movie trailers for films currently showing at the Odeon. Further channels are expected to be added soon.
A programme of investigations and projects that explore the future teaching and learning technology infrastructure that will be regarded as the mainstream for higher education in 15 years time.
Laptops, wireless networks, Web resources, Smartboards and PowerPoint presentations are becoming a normal part of the learning experience for children who are now beginning their primary education. The ECS 2020 Vision is an exploration of the kinds of learning experiences that these children will be having when they graduate from University.
The following projects are part of the ECS 2020 Vision :
Business transactions involve hierarchies of activities whose execution needs to be orchestrated. In standard atomic transactions rollback mechanisms are used to protect against faults by providing all or nothing atomicity for transactions. In so-called long running business transactions rollback is not always possible because parts of a transaction will have been committed or because parts of a transaction (e.g., communications with external agents)are inherently impossible to undo. In such cases compensation can be used as a way of dealing with faults.
We are developing formal approaches to modelling and analysis of compensating transactions.
The Collaborative Orthopaedic Research Environment project aims to offer a Virtual Research environment (VRE) by providing integrated computer support across the research and educational cycles, because these activities are intrinsically coupled as a part of the requirements of the surgeonââ¬â¢s Continuing Professional Development. Research should be undertaken and papers published to achieve goals under the learning contracts with their Professional organisations.
The CORE project will be implemented as a Grid/Web-based environment for supporting a critical subset of the e-science cycle: the collation and analysis of experimental results, the organisation of internal project discussions, and the production of appropriate outline documents depending upon the requirements of conferences and journals selected for dissemination. The CORE will allow surgeons to: create technical material (non research material for education), analyse data (from their own trials or data entered from journals), investigate hypotheses (from their own work or as meta or thematic reviews), discuss the finding from their or others work, and prepare and submit articles for review, using semantic Web services.
In the LICHEN project we propose to extend and complement the work of the UKERNA Wireless Advisory Group and TERENA TF-Mobility (which is establishing a RADIUS-based hierarchy of trust for Location Independent Networking) by investigating and developing a generic system for managing and applying authorisation policy pertaining to resources accessed by users in different administrative domains. These users would typically be members of short-lived, distributed collaborations between multi-site ââ¬â and often multi-disciplinary ââ¬â groups.
Our vision for the Open Middleware Infrstructure Institute (OMII) is for it to become the source for reliable, interoperable and open-source Grid middleware, ensuring the continued success of Grid-enabled e-Science in the UK. We intend
Traditionally, scientists have used paper lab books to capture the process and results of their experiments; these results have then been written up and published in journals, months (or years) later.
The Semantic Web and Semantic Grid, however, are motivating a possible sea change in the way scientists make their work available. With the Semantic Grid, a Web-based technology for sharing data and computation, scientists can share information in richer forms than traditional lab books and publishing has allowed. They will be able to make rafts of data generated in experiments available to other scientists, and to the public for compariosn exploration and study; they can share analyses of information and collaborate in new ways.
At the heart of this new technology-supported endeavor sits very traditional practices: a human scientist writing notes during an experiment into a paper lab book.
To move this crucial data from paper, where only one person can see it at a time, to the Web, where the community can benefit from it, we need innovative means of data capture that support how scientists work.
The myTea Best Practice project is about taking the lessons learned from the Smart Tea project in CombeChem (about capturing previously paper-based information into new digital forms) and applying that within the myGrid eScience project's work to support Bioinformaticians.
The myTea project is a year long collaboration between Smart Tea/CombeChem (University of Southampton) and myGrid (University of Mancher) eScience projects to develop an integrated experimental capture system for bioinformatitians. The project is funded by EPSRC.